Newsletters, articles, podcasts, videos, calculators and more. Clinical trials are research studies that involve people. Code updates northern new england clinical oncology society. Zivaflibercept is used in combination with other medications to treat colorectal cancer. Aflibercept is an isoosmotic solution 300 mosmkg, whereas ziv aflibercept has an osmolarity of 1,000 mosmkg. According to the manufacturer, ziv aflibercept or breastfeeding should be discontinued because of the potential for serious adverse reactions in nursing infants from ziv aflibercept. The osmolarity of aflibercept is 250 to 260 mosm, whereas the osmolarity of ziv aflibercept is 815 to 820 mosm. Ziv aflibercept will be given as a single line of therapy. Zivaflibercept contains the same drug, aflibercept, as the intravitreal preparation, eylea, used in the treatment of macular degeneration. Ziv aflibercept may cause you to develop a hole in the wall of your stomach or intestine.
In countries where aflibercept is unavailable or financially prohibitive, researchers have found early evidence that intravitreal ziv aflibercept might be a safe and. Steady state concentrations of free zivaflibercept were reached by the second dose. Ziv aflibercept is used in combination with other medications to. Zaltrap zivaflibercept dose, indications, adverse effects.
This detailed description can be identified in an hcpcs coding book. The clinical trials on this list are studying zivaflibercept. Listing a study does not mean it has been evaluated by the u. Hcpcs 2019 level ii professional hcpcs level ii american. Since april 1, 2012, the hcpcs level ii code set has undergone approximately 150 individual changes, not.
Zivaflibercept is an analog of aflibercept, containing the same active molecule in a different buffer solution, and its recent availability has prompted numerous preclinical and clinical trials addressing its viability for intraocular use, summarized herein. J9400 injection, zivaflibercept, 1 mg the above description is abbreviated. Zivaflibercept in ocular disease requiring antivegf injection zaltrap the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ziv aflibercept works by changing the amount of blood that gets to the tumor. Animal studies have shown that solutions of less than 500 mosm cause no retinal. Zivaflibercept will not be used in combination with the same irinotecan based regimen that was previously used in. Intravitreal zivaflibercept for recurrent macular edema. Clinical trials look at new ways to prevent, detect, or treat disease.
J9400 hcpcs code inj, zivaflibercept, 1mg hcpcs registry. It is used in patients who have already been treated with other cancer medicines that did not work well. Zivaflibercept zaltrap medical clinical policy bulletins aetna. Sep 05, 2019 along with its needed effects, ziv aflibercept may cause some unwanted effects.
Ziv aflibercept was designed to be a highaffinity blocker of vegfa, with a favorable pharmacokinetic and immunogenicity profile. This is a serious and possibly lifethreatening condition. Compare prices, print coupons and get savings tips for zaltrap zivaflibercept and other colon cancer drugs at cvs, walgreens, and other pharmacies. Zivaflibercept injection come as a solution to be injected intravenously into a vein over at least 1 hour by a doctor or nurse in a medical facility. Hcpcs code j9400 for injection, zivaflibercept, 1 mg. All trials on the list are supported by nci ncis basic information about clinical trials explains the types and phases of trials and how they are carried out. Ndc code 0024584001 is assigned to a package of 1 vial in 1 carton 4 ml in 1 vial of zaltrap, a human prescription drug labeled by sanofiaventis u.
It was developed by regeneron pharmaceuticals and is approved in the united states and europe. It was approved by fda in august 2012, for the treatment of resistant metastatic colorectal carcinoma. Find patient medical information for zivaflibercept intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Zaltrap zivaflibercept is the generic name for the trade name drug zaltrap. It works by keeping new blood vessels from forming in a fastgrowing tumor. Free zivaflibercept concentrations appear to exhibit linear pharmacokinetics in the dose range of 2 mg per kg to 9 mg per kg. Zivaflibercept drug information indications, dosage. Now, a similar story is unfolding overseas with the vegfblocking intravitreal drug aflibercept eylea and the related cancer chemotherapy agent, ziv aflibercept zaltrap. Jul 01, 2015 ziv aflibercept in ocular disease requiring antivegf injection zaltrap the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Ziv aflibercept is used in combination with other medications to treat colorectal cancer. Zivaflibercept was designed to be a highaffinity blocker of vegfa, with a favorable pharmacokinetic and immunogenicity profile.
Zaltrap ziv aflibercept injection for intravenous infusion is a recombinant fusion protein consisting of vascular endothelial growth factor fused to the fc portion of human igg indicated for patients with metastatic colorectal cancer mcrc. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Zivaflibercept intravenous route description and brand. Aflibercept, sold under the brandname eylea and zaltrap, is a medication used to treat wet. Drugs administered other than oral method, chemotherapy drugs. Aflibercept, sold under the brandname eylea and zaltrap, is a medication used to treat wet macular degeneration and metastatic colorectal cancer. Hcpcs code j9400 the healthcare common prodecure coding system hcpcs is a collection of codes that represent procedures, supplies, products and services which may be provided to medicare beneficiaries and to individuals enrolled in private health insurance programs. Aflibercept is an isoosmotic solution 300 mosmkg, whereas ziv aflibercept is more concentrated 1,000 mosmkg. Zaltrap zivaflibercept injection chemotherapy, side.
Patients received intravenous ziv aflibercept 6 mg kg1, pemetrexed 500 mg m2, and cisplatin 75 mg m2, every 21 days for up to 6 cycles. Maintenance administration of ziv aflibercept was to continue until disease progression, intolerable toxicity or other cause for withdrawal. Hcpcs code j9400 for injection, ziv aflibercept, 1 mg. Zivaflibercept is used in combination with other medications to. Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. E vidence from many randomized trials has made antivegf therapy the standard of care for various retinal diseases, such as agerelated macular degeneration, venous occlusions, and diabetic macular edema. The medicare contractor for jurisdiction 1 overpaid a.
J9400 hcpcs code descriptors injection, ziv aflibercept, 1 mg. Start with 14 days free trail along with cpt hcpcs crosswalk. Zivaflibercept as a possible alternative to aflibercept. The accumulation ratio for free ziv aflibercept was approximately 1. Pdf zivaflibercept in macular disease researchgate. Zivaflibercept may provide another antivegf treatment option. Check with your doctor or nurse immediately if any of the following side effects occur while taking zivaflibercept. Zivaflibercept in metastatic colorectal cancer anuj patel, weijing sun division of hematologyoncology, university of pittsburgh cancer institute, university of pittsburgh school of medicine, pittsburgh, pa, usa abstract. Zivaflibercept is made from a human antibody fragment.
Do not start using the medicine for at least 4 weeks after surgery, or until your surgical incision heals. Use ziv aflibercept during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Steady state concentrations of free ziv aflibercept were reached by the second dose. Now, a similar story is unfolding overseas with the vegfblocking intravitreal drug aflibercept eylea and the related cancer chemotherapy agent, zivaflibercept zaltrap. Zivaflibercept is also being studied in the treatment of other types of cancer. Zivaflibercept injection is given together with other medicines eg, fluorouracil, irinotecan, leucovorin to treat advanced cancer of the colon or rectum. A major difference between the 2 medications is osmolarity. Aetna considers zivaflibercept zaltrap medically necessary for the treatment of adults with advanced or metastatic colorectal cancer, appendiceal.
Clinical trials using zivaflibercept national cancer. Nov 09, 2018 ziv aflibercept is made from a human antibody fragment. Beginning july 2012, providers billed medicare using hcpcs code q2046 and then changed to j0178 effective january 20. Full text zivaflibercept in metastatic colorectal cancer btt. The accumulation ratio for free zivaflibercept was approximately 1. Safety and bioavailability of complete and halfdose. Zivaflibercept works by changing the amount of blood that gets to the tumor. It can also lower the number of platelets, which are necessary for proper blood clotting. May, 2016 3 month outcome of ziv aflibercept for dme the safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
J9400 is a valid 2019 hcpcs code for injection, zivaflibercept, 1 mg or just inj, zivaflibercept, 1mg for short, used in medical care. Zivafliberceptzaltrap generic is a recombinant fusion protein, prescribed for metastatic colorectal cancer mcrc along with other medications. Use this comprehensive reference for the hcpcs code set that focuses on management of reimbursement. J9400 hcpcs code descriptors injection, zivaflibercept, 1 mg. Zivaflibercept is usually given once every 14 days. Zivaflibercept zaltrap medical clinical policy bulletins. Ziv aflibercept will not be given concomitantly with cetuximab, panitumumab, or bevacizumab.
Injection, zivaflibercept, 1 mg j9400 hcpcs codes aapc coder. Start with 14 days free trail along with cpthcpcs crosswalk. Free ziv aflibercept concentrations appear to exhibit linear pharmacokinetics in the dose range of 2 mg per kg to 9 mg per kg. It was developed by regeneron pharmaceuticals and is approved in the united states and europe it is an inhibitor of vascular endothelial growth factor vegf. Use zivaflibercept during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Careassist representatives are able to provide coding and billing information and assist with complex reimbursement questions. Jan 31, 2020 this medicine may cause harm to an unborn baby. Ziv aflibercept will not be used in combination with the same irinotecan based regimen that was previously used in combination with bevacizumab. Along with its needed effects, zivaflibercept may cause some unwanted effects. In countries where aflibercept is unavailable or financially prohibitive, researchers have found early evidence that intravitreal zivaflibercept might be a safe and. Aflibercept is a drug used for the treatment of patients with agerelated macular degeneration.
Ziv aflibercept in metastatic colorectal cancer anuj patel, weijing sun division of hematologyoncology, university of pittsburgh cancer institute, university of pittsburgh school of medicine, pittsburgh, pa, usa abstract. Zivaflibercept intravenous route precautions mayo clinic. A modifier provides the means by which the reporting physician or provider can indicate that a service or procedure that has been performed has been altered by some specific circumstance but not changed in its definition or code. Ziv aflibercept can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. Overview zaltrap, in combination with folfiri 5fluorouracil 5fu, leucovorin, and irinotecan, is indicated for patients with. Page 2 of 2 zivaflibercept will be given as a single line of therapy. Zaltrap zivaflibercept injection for intravenous infusion.
Zivaflibercept is approved to be used with folfiri to treat. If you experience any of the following symptoms, call your doctor immediately. J9371j9999 chemotherapy drugs hcpcs codes list 2020. Women must use birth control while taking zivaflibercept systemic and for some time after the last dose. Clinical trials using zivaflibercept national cancer institute. Hcpcs code j9400 for injection, zivaflibercept, 1 mg as maintained by cms falls under chemotherapy drugs. Intravitreal zivaflibercept for recurrent macular edema secondary to central retinal venous occlusion.
Take your hcpcs coding compliance up a notch with related medicare transmittals and manuals right at code level. Zivaflibercept in ocular disease requiring antivegf. Zivaflibercept will not be given concomitantly with cetuximab, panitumumab, or bevacizumab. Side effects of zaltrap zivaflibercept injection for. In some cases, health care professionals may use the trade name zaltrap when referring to the generic drug name zivaflibercept.
Hcpcs procedure and supply medical codes durable medical. Every year, thousands of americans are prescribed zaltrap by their doctors to treat colon cancer. Ziv aflibercept injection is given together with other medicines eg, fluorouracil, irinotecan, leucovorin to treat advanced cancer of the colon or rectum. Zaltrap zivaflibercept injection for intravenous infusion is a recombinant fusion protein consisting of vascular endothelial growth factor fused to the fc portion of human igg indicated for patients with metastatic colorectal cancer mcrc what are side effects of zaltrap. The latter guide is published monthly and is the official companion to the cpt book. Zivaflibercept side effects, dosage, interactions drugs. The combination of cytotoxic chemotherapy and antiangiogenic agents has become a conventional treatment option for patients with metastatic colorectal cancer. Carriers are quick to spot improper hcpcs code billing. Ziv aflibercept is made from a human antibody fragment.
Hcpcs 2019 level ii professional hcpcs level ii american medical assn. Hemorrhage, gastrointestinal perforation, compromised wound healing severe and sometimes fatal hemorrhage, including gastrointestinal gi hemorrhage, has been reported in the patients who have received zaltrap in combination with folfiri. J9400 hcpcs code for injection, zivaflibercept, 1 mg. To prevent potential medication errors the fda required the addition of the prefix ziv to the generic name of the intravenous agent, zivaflibercept. Sanofi genzyme is committed to providing access and reimbursement support to patients. C9296 injection, zivaflibercept, 1 mg the above description is abbreviated. Check with your doctor or nurse immediately if any of the following side effects occur while taking ziv aflibercept. In 2017, injections of aflibercept hcpcs code j0178 were responsible for the most billing to. Aflibercept is an isoosmotic solution 300 mosmkg, whereas zivaflibercept is more concentrated 1,000 mosmkg. Regeneron, new york, usa, antivegf drug, is a recombinant fusion protein with a similar mechanism to aflibercept.
Initial clinical experience a possible lowercost alternative for antivegf therapy. Zaltrap zivaflibercept injection, for intravenous use. A pregnancy test will be done before you start zivaflibercept systemic to show that you are not pregnant. It was approved by fda in august 2012, for the treatment of resistant metastatic. Colorectal cancer that has metastasized spread to other parts of the body. Ziv aflibercept is approved to be used with folfiri to treat. J9371j9999 hcpcs list covering codes for chemotherapy drugs. Zivaflibercept can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection.
In the rabbits that received zivaflibercept ivt injection, vitreous osmolarity in the right eye at baseline was 306 mosm in rabbit 1 and 296 mosm in rabbit 2. Ziv aflibercept can cause problems with wound healing, which could result in bleeding or infection. Ziv aflibercept, which has the same mechanism of action as aflibercept, is a systemic chemotherapeutic agent approved for use in treating colorectal cancer. Ziv aflibercept is also being studied in the treatment of other types of cancer. Coding books containing hcpcs level ii codes and other resources for those billing for durable medical equipment dme, injections, medicare services, drugs and medical supplies. Our purpose is to determine if ziv aflibercept can be used in amd and dme without ocular toxicity, to test the. According to the manufacturer, zivaflibercept or breastfeeding should be discontinued because of the potential for serious adverse reactions in nursing infants from zivaflibercept. Preclinical investigations of intravitreal zivaflibercept article pdf available in ophthalmic surgery lasers and imaging retina 456. Although not all of these side effects may occur, if they do occur they may need medical attention. Preclinical investigations of intravitreal zivaflibercept. This code description may also have includes, excludes, notes, guidelines, examples and other information. It is an inhibitor of vascular endothelial growth factor.
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